(050) Low Prolactin Level Identifies Hypoactive Sexual Desire Disorder Women With a Reduced Inhibition Profile

Abstract Introduction Data on the role of prolactin (PRL) in physiologic range female sexual response are scanty. Objective To investigate association between PRL and function as assessed by Female Sexual Function Index (FSFI). We explored presence a cut-off level able to identify Hypoactive Desire Disorder (HSDD). Methods N=264 pre- post-menopausal women consulting for FSD sexually active were included this observational, retrospective study. A clinical, biochemical psychosexual evaluation was performed. Main Outcome measures: FSFI, Distress Scale-Revised, Middlesex Hospital Questionnaire excitation/sexual inhibition scale (SIS/SES). HSDD diagnosed through clinical interview. Results In multivariate model, showed significant, positive correlation with FSFI (p=0.009) Satisfaction (p=0.011). Women V quintile (14.58-24.59 μg/L) reported significantly higher scores than those I (5.12-6.53 μg/L). presented lower without (p=0.032). ROC curve analysis an accuracy 0.610+-0.044 (p=0.014) predicting HSDD. With threshold 9.83 μg/L, sensitivity specificity 63% 56%, respectively. Subjects =9.83 μg/L. The difference SIS1 score independent cortisol. Conclusions Among normo-PRL levels, lowest levels demonstrated poorer desire highest levels. <9.83 μg/L could predict inhibitory trait. Disclosure Any authors act consultant, employee or shareholder industry for: LV received scientific research grants, advisory board attendance speaker honoraria from Therascience, Theramex, Bayer Schering Pharma, Intercept, Lipocine, Ibsa.